Featherweight champion Ilia Topuria makes his first title defense Saturday against former champion Max Holloway in the main event of UFC 308. The main card is set for 2 p.m. ET from Etihad Arena in Abu Dhabi.  

Topuria is a -255 favorite (risk $255 to win $100), while Holloway fetches a price of +205 (risk $100 to win $205) in the latest MMA odds for UFC 308: Topuria vs. Holloway. Before locking in your picks for UFC 308: Topuria vs. Holloway, make sure you see the MMA predictions and betting advice from SportsLine expert Daniel Vithlani. 

Vithlani is a highly analytical UFC bettor who has been a consistent winner for SportsLine members since making his debut in January 2023 with a 5-0 record for UFC 283. In fact, he's up over $1,500 on his UFC main-card picks!

His other highlights include calling an upset for Sean O'Malley (+210) against Aljamain Sterling (-250) at UFC 292 as part of a 4-1 main card and his UFC 299 winners included underdog selections on Dustin Poirier (+190) against Benoit Saint Denis (-230) and Michael Page (+110) against Kevin Holland (-130). Anyone who has followed him is WAY UP!

This week at UFC 308: Topuria vs. Holloway, we can tell you Vithlani is backing Lerone Murphy (-250) over Dan Ige (+200) in a battle of featherweight contenders on the main card. 

Vithlani has strong picks for Topuria vs. Holloway and other bouts on the UFC 308 card. He's also backing a fighter who "appears to be at the top of his game" You ABSOLUTELY need to see his UFC 308 picks before making any of your own!

Who wins UFC 308: Topuria vs. Holloway, and which fighter is a MUST-BACK? Join SportsLine now to see which fighters you need to be all over, all from the expert who profited more than $1,500 on UFC main-card picks!